Evidence for ozone formation in human atherosclerotic arteries.
نویسندگان
چکیده
Here, we report evidence for the production of ozone in human disease. Signature products unique to cholesterol ozonolysis are present within atherosclerotic tissue at the time of carotid endarterectomy, suggesting that ozone production occurred during lesion development. Furthermore, advanced atherosclerotic plaques generate ozone when the leukocytes within the diseased arteries are activated in vitro. The steroids produced by cholesterol ozonolysis cause effects that are thought to be critical to the pathogenesis of atherosclerosis, including cytotoxicity, lipid-loading in macrophages, and deformation of the apolipoprotein B-100 secondary structure. We propose the trivial designation "atheronals" for this previously unrecognized class of steroids.
منابع مشابه
Can Allergic Disorders Decrease the Risk of Thromboembolic Events in Atherosclerosis? an Evidence-based Review
Atherosclerosis is a complex inflammatory disorder of the medium and large-sized arteries. Recent experiments demonstrated that atherosclerosis is a Th1 dominant autoimmune condition, whereas Th2 cells are rarely detected within the atherosclerotic lesions. Several studies have indicated that Th2 type cytokines could be effective in the reduction and stabilization of atherosclerotic plaque. The...
متن کاملDoes HTLV-1 infection lead to increased intima-media thickness (IMT)? “Evidences form human clinical studies”
Briefly, based on the previous evidence and the results of the present study, it seems that infection with HTLV-1 by destruction of sub-layers of arteries, especially the intima layer, leads to disruption of the integrity of sub-layers of arteries and through various mechanisms, causing the sub-layer’s destruction, increasing the intima-media thickness, changing the lipid profile, and developme...
متن کاملDifferential leukotriene constrictor responses in human atherosclerotic coronary arteries.
BACKGROUND Leukotrienes are a class of biologically active lipids that have potent effects on the heart. To assess their role in coronary artery disease, we compared the contractile responses of leukotriene C4 (LTC4) and leukotriene D4 (LTD4) and their binding activity in both atherosclerotic and nonatherosclerotic human coronary arteries. We also studied expression of the enzymes that control ...
متن کاملPrevalence of Atherosclerotic Plaques in Autopsy Cases with Noncardiac Death
Background and Objective: Ischemic heart disease (IHD) following atherosclerosis is the most common cause of cardiac deaths world wide. We aimed to investigate the pathologic features of atherosclerosis in non cardiac death cases to have an estimate of atherosclerosis prevalence in Mashad (North east of Iran). Patients and Methods : This descriptive (cross sectional) study was done, during ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Science
دوره 302 5647 شماره
صفحات -
تاریخ انتشار 2003